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KMID : 0829220220460060111
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Korean Journal of Oral and Maxillofacial Pathology
2022 Volume.46 No. 6 p.111 ~ p.123
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Functional Relationship between Porphyromonas Gingivalis-driven Periodontal Disease and Alzheimer's Dementia
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Boo Ka-Young
Lee Ji-Hye
Choi Dae-Sol
Gwak Hye-Won
Jeon Da-Eun
Kang Su-Eun
Lee Min-Seo
Park Tae-Young
Shim Hyeon-Ryong
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Abstract
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Periodontitis, especially in its chronic form, is one of the leading causes of tooth loss, significantly affecting the quality of life in the modern era of aging society. Recent studies have revealed a potential correlation between periodontitis and various systemic diseases, including cardiovascular diseases and Alzheimer’s dementia (AD). With the body of epidemiologic evidence that links these separate disease entities, several lines of hypotheses have been postulated to provide mechanistic understandings that mostly comprises abnormal regulation of immunologic and inflammatory signaling. In this review, we revisit the experimental findings that describe virulence factors derived from Porphyromonas Gingivalis, including gingipains and lipopolysaccharides, as well as their roles in the pathophysiology of AD. In addition, we address potential immunologic challenges imposed by this bacterial pathogen contributing to progression of AD.
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KEYWORD
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Periodontitis , Porphyromonas Gingivalis , Alzheimer’s dementia , Gingipains , Lipopolysaccharides
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